By T. H. Crook III Ph.D., G. J. Larrabee (auth.), Prof. Dr. Lüder Deecke, Prof. Dr. Peter Dal-Bianco (eds.)
The papers compiled during this supplementum are a range of the easiest con th tributions awarded on the 19 Central-European Neurological Symposium (CNS 19) hung on June 29 - July 1, 1989 in Vienna. the most subject of this convention used to be degenerative and age-associated neurological ailments. In fresh a long time existence expectancy has dramatically elevated, not less than within the industrialized nations. This has resulted in severe distortions of the so-called inhabitants pyramids that now not seem like such yet start to virtually resemble cylinders. due to this "overaging" of the inhabitants, ailments which are linked to age became even more universal than prior to. It was once hence greater than moderate to dedicate a congress of the CNS sequence to those very important neurological illnesses. the next fields of curiosity are coated: Age-associated reminiscence impairment (AAMI), Alzheimer's and different dementias, Parkinson's disorder and different circulation issues, stroke and others. about the de males tias, a few papers take care of prognosis using neuro-imaging tools akin to MRI, CT, puppy and SPECT, others utilizing electrophysiological tools. a huge element within the early preclinical analysis of dementia is the inclusion of neuropsychological assessments to augment the opportunity of effec tive early therapy. additionally medicines which are now less than scientific research are mentioned and initial effects are presented.
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Additional info for Age-associated Neurological Diseases
Dev Neuropsychol 2: 261-276 Cummings JL, Miller B, Hill MA, Neshkes R (1987) Neuropsychiatric aspects of multiinfarct dementia and dementia of the Alzheimer type. Arch Neurol 44: 389-393 Danielczyk W, Fischer P, Gatterer G, Simanyi M (1989) Depression in the course of MID and DAT. J Neural Transm (P-D Sect) 1: 44 Deutsch G, Tweedy JR (1987) Cerebral blood flow in severity-matched Alzheimer and multi-infarct patients. Neurology 37: 431-438 Duara R, Grady C, Haxby J, Sundaram M, Cutler NR, Heston L, Moore A, Schlageter N, Larson S, Rapoport SI (1986) Positron emission tomography in Alzheimer's disease.
However, neurons with early (especially stage 1) tangles frequently revealed cytoplasmic reactivity in the pericaryon and dendrites with a monoclonal antibody against a phosphorylated epitope of neurofilaments (SMI 31). That seems to point to a more complex disorder of the cytoskeleton from which the conditions for production of NFT as a not strictly specific type of neuronal reaction originate. In summary the results of our examination of Alzheimer NFT indicate that pathologically phosphorylated tau epitopes appear at the earliest stages of NFT formation.
1986). , 1988). The differentiation between MID and DAT The diagnostic evaluation of a questionable demented patient has to be carried out in 3 steps. The first step is to decide whether the patient is really demented: delirium, focal neurological deficit and pseudodementia due to depression or schizophrenia has to be excluded (Marsden, 1985). , 1990). Then follows the exclusion of dementing conditions other than MID or DA T and the exclusion of treatable dementias, especially (hypothyreosis, vitamine B 12-deficiency, chronic Wernicke-encephalopathy, frontal meningioma, progressive paralysis, ...