Structural

Aliphatic and Polyhalogenated Carcinogens: Structural Bases by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos

By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos

Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer causing agents of commercial origins.
The booklet discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and comparable aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental importance of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental importance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The publication additional tackles the structure-activity relationships, metabolism, and environmental importance if fatty acids, detergents, and different surfactants with oncogenic capability. The textual content then appears to be like into the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic task.
Chemists, geneticists, and people fascinated with melanoma learn will locate the booklet helpful.

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Extra info for Aliphatic and Polyhalogenated Carcinogens: Structural Bases and Biological Mechanisms: 3

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The hepatocarcinogenicity of CC14 in the mouse has also been confirmed in several other studies using C3H, BuB, XVII/G, and B6C3Fj strains (see Table XI). In an NCI study (234) nearly all the mice (see Table VIII) developed hepatocellular carcinomas by the end of the bioassay. A study by Confer and Stenger (232) showed that CC14 was also hepatocarcinogenic by intrarectal administration. 1 ml of a 40% solution of CC14 in olive oil for 20 to 26 weeks developed liver tumors described as nodular hyperplasia.

T. t. n. t. t. t. b Local Sarcoma After s . c . 1 Halogenated Linear Alkanes and Alkenes I 35 Table X Relative Carcinogenic Potency of Haloalkanes and Haloalkenes (Pulmonary Adenoma Bioassay)3 Total DoseD Compound Negative c o n t r o l s Iodomethane (methyl No. 2 Organohalogens, H-Bond Reactors, Surfactant Types Table X (Continued) Compound T o t a l Dose" 1-Bromo-2-me t h y l p r o p a n e ( i - b u t y l bromide) 2-Bromobutane ( s - b u t y l bromide) 2-Bromo-2-me t h y l p r o p a n e ( t - b u t y l bromide) 1-Iodobutane Çn-butyl i o d i d e ) 2-Iodobutane (£-butyl iodide) 2-Iodo-2-me thylpropane (_t-butyl iodide) No.

However, exceptions to this rule, such as the lack of mutagenicity of trichloroethylene (182) and the positive result with tetrachloroethylene (164), have been observed by some investigators. In addition, the mutagenicity of eis- and trans- 1,2-dichloroethylene has not been adequately tested. l,l-Difluoro-2-bromo-2-chloroethene, a presumed metabolite of halothane, appears to be an unusual haloethene; it is mutagenic without metabolic activation (165). In the halopropene series a very good correlation between alkylating and mutagenic activities of at least nine compounds has been noted by Eder et al.

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